Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence

• Main Authors: Shan Geng (Author), Xin-Yi Mu (Author), Xiong-Bin Chen (Author), Ji-Ying Hou (Author), Dao-Yong Jia (Author), Chun-Yan Xu (Author), Ya-Ping Wang (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The researches in the dynamic changes of the progress of HSCs aging are very limited and necessary. In this study, male C57BL/6 mice were divided into 5 groups by age. We found that the superoxide damage of HSPCs started to increase from the middle age (6 months old), with notably reduced antioxidat...