Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial Hyperpermeability via the Axl/NF-κB Signaling Pathway

• Main Authors: Jingjing Ni (Author), Miaotong Lin (Author), Yangjie Jin (Author), Jiajia Li (Author), Yayong Guo (Author), Jindong Zhou (Author), Guangliang Hong (Author), Guangju Zhao (Author), Zhongqiu Lu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular endothelial functional dysregulation and barrier disruption are involved the initiation and development of sepsis. Growth arrest-specific protein 6 (Gas6), one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), is confirmed to have beneficial functions in hemostasis, inflam...