Genotypic characterization directly applied to sputum improves the detection of Mycobacterium africanum West African 1, under-represented in positive cultures.

• Main Authors: C N'Dira Sanoussi (Author), Dissou Affolabi (Author), Leen Rigouts (Author), Séverin Anagonou (Author), Bouke de Jong (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to compare the prevalence of Mycobacterium tuberculosis complex (MTBc) lineages between direct genotyping (on sputum) and indirect genotyping (on culture), to characterize potential culture bias against difficult growers.Smear-positive sputa from consecutive new tuberculosis patient...