Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated <em>NOD2</em> Mutations

• Автори: Mizuho Nishiyama (Автор), Hong-jin Li (Автор), Ikuo Okafuji (Автор), Akihiko Fujisawa (Автор), Mizue Ehara (Автор), Naotomo Kambe (Автор), Fukumi Furukawa (Автор), Nobuo Kanazawa (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2021-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Objectives: Blau syndrome is a distinct class of autoinflammatory syndrome presenting with early-onset systemic granulomatosis. Blau syndrome-causing <i>NOD2</i> mutations located in the central nucleotide-oligomerization domain induce ligand-independent basal NF-κB activation in an in v...