Sustained Surface ICAM-1 Expression and Transient PDGF-B Production by Phorbol Myristate Acetate-Activated THP-1 Cells Harboring Blau Syndrome-Associated <em>NOD2</em> Mutations

• Main Authors: Mizuho Nishiyama (Author), Hong-jin Li (Author), Ikuo Okafuji (Author), Akihiko Fujisawa (Author), Mizue Ehara (Author), Naotomo Kambe (Author), Fukumi Furukawa (Author), Nobuo Kanazawa (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Blau syndrome is a distinct class of autoinflammatory syndrome presenting with early-onset systemic granulomatosis. Blau syndrome-causing <i>NOD2</i> mutations located in the central nucleotide-oligomerization domain induce ligand-independent basal NF-κB activation in an in v...