Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

• Main Authors: Knut Biber (Author), Anindya Bhattacharya (Author), Brian M. Campbell (Author), Justin R. Piro (Author), Michael Rohe (Author), Roland G.W. Staal (Author), Robert V. Talanian (Author), Thomas Möller (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is a large and increasing unmet medical need with no disease-modifying treatment currently available. Genetic evidence from genome-wide association studies (GWASs) and gene network analysis has clearly revealed a key role of the innate immune system in the brain, of whi...