Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

• Main Authors: Nathan M Belliveau (Author), Jens Huft (Author), Paulo JC Lin (Author), Sam Chen (Author), Alex KK Leung (Author), Timothy J Leaver (Author), Andre W Wild (Author), Justin B Lee (Author), Robert J Taylor (Author), Ying K Tam (Author), Carl L Hansen (Author), Pieter R Cullis (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipid nanoparticles (LNP) are the leading systems for in vivo delivery of small interfering RNA (siRNA) for therapeutic applications. Formulation of LNP siRNA systems requires rapid mixing of solutions containing cationic lipid with solutions containing siRNA. Current formulation procedures employ m...