Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

• Главные авторы: Nathan M Belliveau (Автор), Jens Huft (Автор), Paulo JC Lin (Автор), Sam Chen (Автор), Alex KK Leung (Автор), Timothy J Leaver (Автор), Andre W Wild (Автор), Justin B Lee (Автор), Robert J Taylor (Автор), Ying K Tam (Автор), Carl L Hansen (Автор), Pieter R Cullis (Автор)
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• Опубликовано: Elsevier, 2012-01-01T00:00:00Z.
• Предметы: article
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Lipid nanoparticles (LNP) are the leading systems for in vivo delivery of small interfering RNA (siRNA) for therapeutic applications. Formulation of LNP siRNA systems requires rapid mixing of solutions containing cationic lipid with solutions containing siRNA. Current formulation procedures employ m...