Integrated analysis of single-cell and bulk transcriptome reveals hypoxia-induced immunosuppressive microenvironment to predict immunotherapy response in high-grade serous ovarian cancer

• Váldodahkkit: Qingshan Chen (Dahkki), Yue Zhang (Dahkki), Chao Wang (Dahkki), Hui Ding (Dahkki), Liqun Chi (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

BackgroundHypoxia is significantly associated with cancer progression and treatment outcomes. Nevertheless, the precise molecular mechanisms underlying the hypoxia-induced immunosuppressive microenvironment in high-grade serous ovarian cancer (HGSOC) are still not fully understood.MethodsBy analyzin...