Integrated analysis of single-cell and bulk transcriptome reveals hypoxia-induced immunosuppressive microenvironment to predict immunotherapy response in high-grade serous ovarian cancer

• Auteurs principaux: Qingshan Chen (Auteur), Yue Zhang (Auteur), Chao Wang (Auteur), Hui Ding (Auteur), Liqun Chi (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

BackgroundHypoxia is significantly associated with cancer progression and treatment outcomes. Nevertheless, the precise molecular mechanisms underlying the hypoxia-induced immunosuppressive microenvironment in high-grade serous ovarian cancer (HGSOC) are still not fully understood.MethodsBy analyzin...