Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new "non-natural" analogues

• Asıl Yazarlar: Ke Ma (Yazar), Yuting Zhang (Yazar), Cui Guo (Yazar), Yanlong Yang (Yazar), Junjie Han (Yazar), Bo Yu (Yazar), Wenbing Yin (Yazar), Hongwei Liu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2021-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Mushroom-derived cyathane-type diterpenes possess unusual chemical skeleton and diverse bioactivities. To efficiently supply bioactive cyathanes for deep studies and explore their structural diversity, de novo synthesis of cyathane diterpenes in a geranylgeranyl pyrophosphate engineered Saccharomyce...