Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new "non-natural" analogues

• Główni autorzy: Ke Ma (Autor), Yuting Zhang (Autor), Cui Guo (Autor), Yanlong Yang (Autor), Junjie Han (Autor), Bo Yu (Autor), Wenbing Yin (Autor), Hongwei Liu (Autor)
• Format: Książka
• Wydane: Elsevier, 2021-09-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Mushroom-derived cyathane-type diterpenes possess unusual chemical skeleton and diverse bioactivities. To efficiently supply bioactive cyathanes for deep studies and explore their structural diversity, de novo synthesis of cyathane diterpenes in a geranylgeranyl pyrophosphate engineered Saccharomyce...