Evaluation of the Solid Dispersion System Engineered from Mesoporous Silica and Polymers for the Poorly Water Soluble Drug Indomethacin: In Vitro and In Vivo

• Egile Nagusiak: Ziyue Xi (Egilea), Wei Zhang (Egilea), Yali Fei (Egilea), Mingshu Cui (Egilea), Luyao Xie (Egilea), Lu Chen (Egilea), Lu Xu (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

This work explored absorption efficacy via an in vivo imaging system and parallel artificial membrane penetration in indomethacin (IMC) solid dispersion (SD) systems. Two different polymer excipients—hydroxypropyl methylcellulose (HPMC) and Kollicoat IR as precipitation inhibitors (PIs)&am...