Deep sequencing of HIV-1 variants from paired plasma and cerebrospinal fluid during primary HIV infection

• Main Authors: Arjet Gega (Author), Michael J. Kozal (Author), Jennifer Chiarella (Author), Evelyn Lee (Author), Julia Peterson (Author), Frederick M. Hecht (Author), Teri Liegler (Author), Elizabeth P. St John (Author), Birgitte B. Simen (Author), Richard W. Price (Author), Serena S. Spudich (Author)
• Format: Book
• Published: Elsevier, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Limited data exist comparing viral quasispecies between cerebrospinal fluid (CSF) and plasma compartments during primary HIV infection. Deep sequencing is a new method to examine the HIV plasma and CSF quasispecies. Methods: In this pilot study, deep sequencing of protease (PR) and rever...