α-Phenyl-N-tert-butyl Nitrone Has Scavenging Activity Against Singlet Oxygen (1O2) and Attenuates 1O2-Induced Neuronal Cell Death

• Main Authors: Anna Kawai (Author), Yoko Nishinaka (Author), Toshiyuki Arai (Author), Kiichi Hirota (Author), Hiroko Mori (Author), Nobuyuki Endo (Author), Takashi Miyoshi (Author), Kouhei Yamashita (Author), Masataka Sasada (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scavenging activity of α-phenyl-N-tert-butyl nitrone (PBN) against singlet oxygen (1O2) and its effects on 1O2-induced neuronal cell death were examined. PBN at 1-4mM dose-dependently suppressed 1O2 released from activated human neutrophils. PBN did not react with hydrogen peroxide or hypochlorite a...