Plant-Derived Extracellular Vesicles as a Delivery Platform for RNA-Based Vaccine: Feasibility Study of an Oral and Intranasal SARS-CoV-2 Vaccine

• Main Authors: Margherita A. C. Pomatto (Author), Chiara Gai (Author), Federica Negro (Author), Lucia Massari (Author), Maria Chiara Deregibus (Author), Cristina Grange (Author), Francesco Giuseppe De Rosa (Author), Giovanni Camussi (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Plant-derived extracellular vesicles (EVs) may represent a platform for the delivery of RNA-based vaccines, exploiting their natural membrane envelope to protect and deliver nucleic acids. Here, EVs extracted from orange (<i>Citrus sinensis</i>) juice (oEVs) were investigated as carriers...