MALAT1-miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy
Abstract Background The active metabolite of 5-Fluorouracil (5FU), used in the treatment of several types of cancer, acts by inhibiting the thymidylate synthase encoded by the TYMS gene, which catalyzes the rate-limiting step in DNA replication. The major failure of 5FU-based cancer therapy is the d...
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BMC,
2022-08-01T00:00:00Z.
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