Evaluating Drug Interactions between Ritonavir and Opioid Analgesics: Implications from Physiologically Based Pharmacokinetic Simulation

• Main Authors: Liang Ni (Author), Zhihai Cao (Author), Jiakang Jiang (Author), Wei Zhang (Author), Wei Hu (Author), Qian Zhang (Author), Chaozhuang Shen (Author), Xijing Chen (Author), Liang Zheng (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several commonly used opioid analgesics, such as fentanyl, sufentanil, alfentanil, and hydrocodone, are by report primarily metabolized by the CYP3A4 enzyme. The concurrent use of ritonavir, a potent CYP3A4 inhibitor, can lead to significant drug interactions. Using physiologically based pharmacokin...