Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes

• Main Authors: Brian Lu (Author), Kiran Kurmi (Author), Miguel Munoz-Gomez (Author), Egon J. Jacobus Ambuludi (Author), Jason M. Tonne (Author), Kuntol Rakshit (Author), Taro Hitosugi (Author), Yogish C. Kudva (Author), Aleksey V. Matveyenko (Author), Yasuhiro Ikeda (Author)
• Format: Book
• Published: The Company of Biologists, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in HFD-induced diabetes. However, owing to its crucial roles in glucose metabolism in the liver and in islet β-cells, the contribution of decreas...