Impaired β-cell glucokinase as an underlying mechanism in diet-induced diabetes

• Hoofdauteurs: Brian Lu (Auteur), Kiran Kurmi (Auteur), Miguel Munoz-Gomez (Auteur), Egon J. Jacobus Ambuludi (Auteur), Jason M. Tonne (Auteur), Kuntol Rakshit (Auteur), Taro Hitosugi (Auteur), Yogish C. Kudva (Auteur), Aleksey V. Matveyenko (Auteur), Yasuhiro Ikeda (Auteur)
• Formaat: Boek
• Gepubliceerd in: The Company of Biologists, 2018-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

High-fat diet (HFD)-fed mouse models have been widely used to study early type 2 diabetes. Decreased β-cell glucokinase (GCK) expression has been observed in HFD-induced diabetes. However, owing to its crucial roles in glucose metabolism in the liver and in islet β-cells, the contribution of decreas...