Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the <i>Plasmodium</i> Life Cycle

• Main Authors: Helenita C. Quadros (Author), Aysun Çapcı (Author), Lars Herrmann (Author), Sarah D'Alessandro (Author), Diana Fontinha (Author), Raquel Azevedo (Author), Wilmer Villarreal (Author), Nicoletta Basilico (Author), Miguel Prudêncio (Author), Svetlana B. Tsogoeva (Author), Diogo R. M. Moreira (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent activity against the asexual blood stage of <i>Plasmodium</i>, the malaria parasite. In this study, we determined its in vitro cytotoxicity to mammalian cells, its potency to suppress <i>...