Vasculitis in a Child With the Hyper-IgM Variant of Ataxia-Telangiectasia

• Main Authors: Anna K. Meyer (Author), Mindy Banks (Author), Tibor Nadasdy (Author), Jennifer J. Clark (Author), Rui Zheng (Author), Erwin W. Gelfand (Author), Jordan K. Abbott (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A subset of patients with Ataxia-Telangiectasia (A-T) have dramatically reduced levels of IgG, IgA, and IgE with retained or elevated IgM levels. Several reports suggest that these A-T patients with a "hyper-IgM phenotype" (HIgM) suffer more clinical immunologic consequences than other A-T...