Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity

• Main Authors: András Gyovai (Author), Renáta Minorics (Author), Anita Kiss (Author), Erzsébet Mernyák (Author), Gyula Schneider (Author), András Szekeres (Author), Erika Kerekes (Author), Imre Ocsovszki (Author), István Zupkó (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

19-Nortestosterone C-17 epimers with prominent antiproliferative properties have been previously described. In our present study, five novel 17α-19-nortestosterones (3−7) were synthesized to increase their beneficial biological activities with no associated undesired hormonal effects. The compounds...