Metformin Protects Against Carbon Tetrachloride Hepatotoxicity in Mice

• Main Authors: Michel K.T. Poon (Author), Po-Yee Chiu (Author), Duncan H.F. Mak (Author), Kam-Ming Ko (Author)
• Formato: Livro
• Publicado em: Elsevier, 2003-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

ABSTRACT: In the present study, the hepatoprotective effect of metformin (Met), a dimethylbiguanide anti-hyperglycemic, was examined in a mouse model of liver damage induced by chronic repeated administration of carbon tetrachloride (CCl4) (5 μl/kg, twice a week for 12 weeks). Met, when given orally...