Metformin Protects Against Carbon Tetrachloride Hepatotoxicity in Mice

• Hauptverfasser: Michel K.T. Poon (Verfasst von), Po-Yee Chiu (Verfasst von), Duncan H.F. Mak (Verfasst von), Kam-Ming Ko (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2003-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

ABSTRACT: In the present study, the hepatoprotective effect of metformin (Met), a dimethylbiguanide anti-hyperglycemic, was examined in a mouse model of liver damage induced by chronic repeated administration of carbon tetrachloride (CCl4) (5 μl/kg, twice a week for 12 weeks). Met, when given orally...