Thermal Stability of siRNA Modulates Aptamer- conjugated siRNA Inhibition

• Main Authors: Alexey Berezhnoy (Author), Randall Brenneman (Author), Marcio Bajgelman (Author), Dawn Seales (Author), Eli Gilboa (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oligonucleotide aptamer-mediated in vivo cell targeting of small interfering RNAs (siRNAs) is emerging as a useful approach to enhance the efficacy and reduce the adverse effects resulting from siRNA-mediated genetic interference. A current main impediment in aptamer-mediated siRNA targeting is that...