Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

• Main Authors: Jiafeng Li (Author), Guodong Bao (Author), Eman ALyafeai (Author), Jian Ding (Author), Shihen Li (Author), Shimin Sheng (Author), Zitong Shen (Author), Zhenyu Jia (Author), Chen Lin (Author), Chenxi Zhang (Author), Zhiling Lou (Author), Huazi Xu (Author), Weiyang Gao (Author), Kailiang Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia-reperfusion injury limits clinical applications. Betulinic acid, a plant-derived pentacyclic triterpene, may facilitate flap su...