α-Linoleic Acid Enhances the Capacity of α1-Antitrypsin to Inhibit Lipopolysaccharide-Induced IL-1β in Human Blood Neutrophils

• Main Authors: Nupur Aggarwal (Author), Elena Korenbaum (Author), Ravi Mahadeva (Author), Stephan Immenschuh (Author), Veronika Grau (Author), Charles A Dinarello (Author), Tobias Welte (Author), Sabina Janciauskiene (Author)
• Format: Book
• Published: BMC, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Alphal-antitrypsin (A1AT, SERPINA1), a major circulating inhibitor of neutrophil elastase (NE) and protelnase-3 (PR3), has been proposed to reduce the processing and release of IL-1β. Since the antiinflammatory properties of A1AT are influenced by the presence of polyunsaturated fatty acids...