Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists

• Main Authors: Assunta Cirella (Author), Elixabet Bolaños (Author), Carlos Luri-Rey (Author), Claudia Augusta Di Trani (Author), Irene Olivera (Author), Gabriel Gomis (Author), Javier Glez-Vaz (Author), Beatrice Pinci (Author), Saray Garasa (Author), Sandra Sánchez-Gregorio (Author), Arantza Azpilikueta (Author), Iñaki Eguren-Santamaria (Author), Karmele Valencia (Author), Belén Palencia (Author), Maite Alvarez (Author), Maria C. Ochoa (Author), Álvaro Teijeira (Author), Pedro Berraondo (Author), Ignacio Melero (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. To make the most of these approaches, we have constructed chimeric mRNAs encoding single-chain IL-12 fused to...