Microbial Antigen-Presenting Extracellular Vesicles Derived from Genetically Modified Tumor Cells Promote Antitumor Activity of Dendritic Cells

• Main Authors: Tomoko Ito (Author), Kikuya Sugiura (Author), Aya Hasegawa (Author), Wakana Ouchi (Author), Takayuki Yoshimoto (Author), Izuru Mizoguchi (Author), Toshio Inaba (Author), Katsuyuki Hamada (Author), Masazumi Eriguchi (Author), Yoshiyuki Koyama (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor-derived extracellular vesicles (EVs), as tumor vaccines, carry tumor-associated antigens (TAAs), and were expected to transfer TAAs to antigen-presenting cells. However, treatment with tumor-derived EVs exhibited no obvious antitumor effect on the established tumors, likely due to their immuno...