Preparation and Evaluation of Inhalable Microparticles with Improved Aerodynamic Performance and Dispersibility Using L-Leucine and Hot-Melt Extrusion

• Main Authors: Jin-Hyuk Jeong (Author), Ji-Su Kim (Author), Yu-Rim Choi (Author), Dae Hwan Shin (Author), Ji-Hyun Kang (Author), Dong-Wook Kim (Author), Yun-Sang Park (Author), Chun-Woong Park (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dry-powder inhalers (DPIs) are valued for their stability but formulating them is challenging due to powder aggregation and limited flowability, which affects drug delivery and uniformity. In this study, the incorporation of L-leucine (LEU) into hot-melt extrusion (HME) was proposed to enhance dispe...