Disruption of adipocyte YAP improves glucose homeostasis in mice and decreases adipose tissue fibrosis

• Main Authors: Daniel J. Han (Author), Rukhsana Aslam (Author), Paraish S. Misra (Author), Felix Chiu (Author), Tanvi Ojha (Author), Apu Chowdhury (Author), Carmen K. Chan (Author), Hoon-Ki Sung (Author), Darren A. Yuen (Author), Cynthia T. Luk (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Adipose tissue is a very dynamic metabolic organ that plays an essential role in regulating whole-body glucose homeostasis. Dysfunctional adipose tissue hypertrophy with obesity is associated with fibrosis and type 2 diabetes. Yes-associated protein 1 (YAP) is a transcription cofactor imp...