Pharmacokinetics, pharmacodynamics and safety of 15 mg-tolvaptan administered orally for 7 consecutive days to Chinese patients with child-Pugh B cirrhosis

• Main Authors: Hongzhong Liu (Author), Yongfeng Wang (Author), Tao Liu (Author), Yingxuan Chen (Author), Xin Zheng (Author), Ming Liu (Author), Qian Zhao (Author), Minde Zeng (Author), Ji Jiang (Author), Yimin Mao (Author), Pei Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tolvaptan, a selective vasopressin V2-receptor antagonist, can elicit a diuretic effect without significant electrolyte loss. The aims were to evaluate multiple-dose pharmacokinetics, pharmacodynamics and safety of daily administration of 15 mg tolvaptan in Chinese adult patients with co...