Synthetic Lethal Activity of Benzophenanthridine Alkaloids From Zanthoxylum coco Against BRCA1-Deficient Cancer Cells

• Main Authors: Iris A. García (Author), Maria Florencia Pansa (Author), Adriana Del Valle Pacciaroni (Author), Manuela E. García (Author), Maria Laura Gonzalez (Author), Juan Carlos Oberti (Author), José Luís Bocco (Author), Maria Cecilia Carpinella (Author), Gloria E. Barboza (Author), Viviana E. Nicotra (Author), Gastón Soria (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several plants from South America show strong antitumoral properties based on anti-proliferative and/or pro-apoptotic activities. In this work we aimed to identify selective cytotoxic compounds that target BRCA1-deficient cancer cells by Synthetic Lethality (SL) induction. Using a high-throughput sc...