Generation of HIV-Resistant Macrophages from IPSCs by Using Transcriptional Gene Silencing and Promoter-Targeted RNA

• Main Authors: Kei Higaki (Author), Masako Hirao (Author), Ai Kawana-Tachikawa (Author), Shoichi Iriguchi (Author), Ayako Kumagai (Author), Norihiro Ueda (Author), Wang Bo (Author), Sanae Kamibayashi (Author), Akira Watanabe (Author), Hiromitsu Nakauchi (Author), Kazuo Suzuki (Author), Shin Kaneko (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Highly active antiretroviral therapy (HAART) has markedly prolonged the prognosis of HIV-1 patients. However, lifelong dependency on HAART is a continuing challenge, and an effective therapeutic is much desired. Recently, introduction of short hairpin RNA (shRNA) targeting the HIV-1 promoter was fou...