3-Chloro-N'-(2-hydroxybenzylidene) benzohydrazide: An LSD1-Selective Inhibitor and Iron-Chelating Agent for Anticancer Therapy

• Main Authors: Federica Sarno (Author), Chiara Papulino (Author), Gianluigi Franci (Author), Jeanette H. Andersen (Author), Bastien Cautain (Author), Colombina Melardo (Author), Lucia Altucci (Author), Angela Nebbioso (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite the discovery and development of novel therapies, cancer is still a leading cause of death worldwide. In order to grow, tumor cells require large quantities of nutrients involved in metabolic processes, and an increase in iron levels is known to contribute to cancer proliferation. Iron plays...