1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World <i>Leishmania</i> Parasites: In Vitro Activity and Mode of Action

• Main Authors: Andreia Mendes (Author), Ana Armada (Author), Lília I. L. Cabral (Author), Patrícia S. M. Amado (Author), Lenea Campino (Author), Maria L. S. Cristiano (Author), Sofia Cortes (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmaniasis remains one of the ten Neglected Tropical Diseases with significant morbidity and mortality in humans. Current treatment of visceral leishmaniasis is difficult due to a lack of effective, non-toxic, and non-extensive medications. This study aimed to evaluate the selectivity of 12 synth...