Dual mass spectrometry imaging and spatial metabolomics to investigate the metabolism and nephrotoxicity of nitidine chloride

• Main Authors: Shu Yang (Author), Zhonghua Wang (Author), Yanhua Liu (Author), Xin Zhang (Author), Hang Zhang (Author), Zhaoying Wang (Author), Zhi Zhou (Author), Zeper Abliz (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Evaluating toxicity and decoding the underlying mechanisms of active compounds are crucial for drug development. In this study, we present an innovative, integrated approach that combines air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI), time-of-flight sec...