Rational Development of a Carrier-Free Dry Powder Inhalation Formulation for Respiratory Viral Infections via Quality by Design: A Drug-Drug Cocrystal of Favipiravir and Theophylline

• Main Authors: Si Nga Wong (Author), Jingwen Weng (Author), Ignatius Ip (Author), Ruipeng Chen (Author), Richard Lakerveld (Author), Richard Telford (Author), Nicholas Blagden (Author), Ian J. Scowen (Author), Shing Fung Chow (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Formulating pharmaceutical cocrystals as inhalable dosage forms represents a unique niche in effective management of respiratory infections. Favipiravir, a broad-spectrum antiviral drug with potential pharmacological activity against SARS-CoV-2, exhibits a low aqueous solubility. An ultra-high oral...