New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors

• Main Authors: Chenkai Cui (Author), Xuefei Tian (Author), Linting Wei (Author), Yinhong Wang (Author), Kexin Wang (Author), Rongguo Fu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dipeptidyl peptidase 8 (DPP8) and 9 (DPP9) are widely expressed in mammals including humans, mainly locate in the cytoplasm. The DPP8 and DPP9 (DPP8/9) belong to serine proteolytic enzymes, they can recognize and cleave N-terminal dipeptides of specific substrates if proline is at the penultimate po...