Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype

• المؤلفون الرئيسيون: Marpe Bam (مؤلف), Xiaoming Yang (مؤلف), Brandon P. Busbee (مؤلف), Allison E. Aiello (مؤلف), Monica Uddin (مؤلف), Jay P. Ginsberg (مؤلف), Sandro Galea (مؤلف), Prakash S. Nagarkatti (مؤلف), Mitzi Nagarkatti (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2020-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Posttraumatic stress disorder (PTSD) is a psychiatric disorder accompanied by chronic peripheral inflammation. What triggers inflammation in PTSD is currently unclear. In the present study, we identified potential defects in signaling pathways in peripheral blood mononuclear cell...