Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation

Doxorubicin (DOX) is an anthracycline antibiotic that is used extensively for the management of carcinoma; however, its clinical application is limited due to its serious cardiotoxic side effects. Ferroptosis represents iron-dependent and reactive oxygen species (ROS)-related cell death and has been...

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Main Authors: Danlei Li (Author), Xiaoman Liu (Author), Wenhu Pi (Author), Yang Zhang (Author), Lei Yu (Author), Cheng Xu (Author), Zhenzhu Sun (Author), Jianjun Jiang (Author)
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Publicado: Frontiers Media S.A., 2022-02-01T00:00:00Z.
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