Fragment-based design, synthesis and biological evaluation of theophylline derivatives as ATAD2 inhibitors in BT-549 cells

• Main Authors: Dahong Yao (Author), Jieshu You (Author), Xuetao Yang (Author), Jin Zhang (Author), Xiaojun Yao (Author)
• פורמט: ספר
• יצא לאור: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

ATPase family AAA domain-containing protein 2 (ATAD2) has been emerging as a hot anti-cancer drugable target due to its oncogenic epigenetic modification closely associated with cancer cells proliferation, apoptosis, migration and drug resistance. In this study, we design a series of theophylline de...