A Conserved Target Site in HIV-1 Gag RNA is Accessible to Inhibition by Both an HDV Ribozyme and a Short Hairpin RNA

• Main Authors: Robert J Scarborough (Author), Michel V Lévesque (Author), Etienne Boudrias-Dalle (Author), Ian C Chute (Author), Sylvanne M Daniels (Author), Rodney J Ouellette (Author), Jean-Pierre Perreault (Author), Anne Gatignol (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antisense-based molecules targeting HIV-1 RNA have the potential to be used as part of gene or drug therapy to treat HIV-1 infection. In this study, HIV-1 RNA was screened to identify more conserved and accessible target sites for ribozymes based on the hepatitis delta virus motif. Using a quantitat...