Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors

• मुख्य लेखकों: Simone Giovannuzzi (लेखक), Alessandro Bonardi (लेखक), Paola Gratteri (लेखक), Alessio Nocentini (लेखक), Claudiu T. Supuran (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Considering the unrecognised physio-pathological role of human carbonic anhydrase III (hCA III), a structure-based drug design was set up to identify the first-in-class potent and selective inhibitors of this neglected isoform. hCA III targeting was planned considering a unique feature of its active...