Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors

• المؤلفون الرئيسيون: Simone Giovannuzzi (مؤلف), Alessandro Bonardi (مؤلف), Paola Gratteri (مؤلف), Alessio Nocentini (مؤلف), Claudiu T. Supuran (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Considering the unrecognised physio-pathological role of human carbonic anhydrase III (hCA III), a structure-based drug design was set up to identify the first-in-class potent and selective inhibitors of this neglected isoform. hCA III targeting was planned considering a unique feature of its active...