New Sulfanilamide Derivatives Incorporating Heterocyclic Carboxamide Moieties as Carbonic Anhydrase Inhibitors

• Main Authors: Andrea Angeli (Author), Victor Kartsev (Author), Anthi Petrou (Author), Mariana Pinteala (Author), Roman M. Vydzhak (Author), Svitlana Y. Panchishin (Author), Volodymyr Brovarets (Author), Viviana De Luca (Author), Clemente Capasso (Author), Athina Geronikaki (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic Anhydrases (CAs) are ubiquitous metalloenzymes involved in several disease conditions. There are 15 human CA (hCA) isoforms and their high homology represents a challenge for the discovery of potential drugs devoid of off-target side effects. For this reason, many synthetic and pharmacologi...