Development of Praziquantel sulphonamide derivatives as antischistosomal drugs

• Main Authors: Andrea Angeli (Author), Marta Ferraroni (Author), Fabrizio Carta (Author), Cécile Häberli (Author), Jennifer Keiser (Author), Gabriele Costantino (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The almost empty armamentarium to treat schistosomiasis, a neglected parasitic disorder caused by trematode flatworms of the genus Schistosoma, except Praziquantel (PZQ), urged to find new alternatives to fight this infection. Carbonic Anhydrase from Schistosoma mansoni (SmCA) is a possible new targ...