CoMET: a randomised controlled trial of co-commencement of metformin versus placebo as an adjunctive treatment to attenuate weight gain in patients with schizophrenia newly commenced on clozapine

• Main Authors: Dan Siskind (Author), Anthony W. Russell (Author), Shuichi Suetani (Author), Dylan Flaws (Author), Steve Kisely (Author), Vikas Moudgil (Author), Korinne Northwood (Author), Gail Robinson (Author), James G. Scott (Author), Terry Stedman (Author), Nicola Warren (Author), Karl Winckel (Author), Peter Cosgrove (Author), Andrea Baker (Author)
• Format: Book
• Published: SAGE Publishing, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: There is limited evidence on interventions to minimise weight gain at clozapine commencement. We compared the effect of adjunctive metformin versus placebo at clozapine initiation. Methods: People with schizophrenia commencing on clozapine were randomised to either metformin or placebo f...