Sphingosine kinase 2 and p62 regulation are determinants of sexual dimorphism in hepatocellular carcinoma

• Main Authors: Christopher D. Green (Author), Ryan D.R. Brown (Author), Baasanjav Uranbileg (Author), Cynthia Weigel (Author), Sumit Saha (Author), Makoto Kurano (Author), Yutaka Yatomi (Author), Sarah Spiegel (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality, and its incidence is increasing due to endemic obesity. HCC is sexually dimorphic in both humans and rodents with higher incidence in males, although the mechanisms contributing to these correlations remain unc...