Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

• Päätekijät: Xi-Ling Jiang (Tekijä), Hong-Wu Shen (Tekijä), Donald E. Mager (Tekijä), Stephan Schmidt (Tekijä), Ai-Ming Yu (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2016-09-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

We have shown recently that concurrent harmaline, a monoamine oxidase-A inhibitor (MAOI), potentiates serotonin (5-HT) receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)-induced hyperthermia. The objective of this study was to develop an integrated pharmacokinetic/pharmacodynamic (PK/PD)...