Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

• Asıl Yazarlar: Xi-Ling Jiang (Yazar), Hong-Wu Shen (Yazar), Donald E. Mager (Yazar), Stephan Schmidt (Yazar), Ai-Ming Yu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2016-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

We have shown recently that concurrent harmaline, a monoamine oxidase-A inhibitor (MAOI), potentiates serotonin (5-HT) receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)-induced hyperthermia. The objective of this study was to develop an integrated pharmacokinetic/pharmacodynamic (PK/PD)...