The unfolded protein response has a protective role in yeast models of classic galactosemia

• Main Authors: Evandro A. De-Souza (Author), Felipe S. A. Pimentel (Author), Caio M. Machado (Author), Larissa S. Martins (Author), Wagner S. da-Silva (Author), Mónica Montero-Lomelí (Author), Claudio A. Masuda (Author)
• Format: Book
• Published: The Company of Biologists, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Classic galactosemia is a human autosomal recessive disorder caused by mutations in the GALT gene (GAL7 in yeast), which encodes the enzyme galactose-1-phosphate uridyltransferase. Here we show that the unfolded protein response pathway is triggered by galactose in two yeast models of galactosemia:...