Poloxamer-enhanced solubility of griseofulvin and its related antifungal activity against Trichophyton spp.

• Autores principales: Vanessa Pittol (Autor), Kleyton Santos Veras (Autor), Samuel Kaiser (Autor), Letícia Jacobi Danielli (Autor), Alexandre Meneghello Fuentefria (Autor), George González Ortega (Autor)
• Formato: Libro
• Publicado: Universidade de São Paulo, 2022-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Poorly water-soluble drugs, such as the antifungal drug griseofulvin (GF), exhibit limited bioavailability, despite their high membrane permeability. Several technological approaches have been proposed to enhance the water solubility and bioavailability of GF, including micellar solubilizat...