Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity

Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity

Objective: Growth differentiation factor 15 (GDF15), a stress related cytokine, was recently identified as a novel satiety signal acting via the GFRAL receptor located in the hindbrain. Bitter compounds are known to induce satiety via the release of glucagon-like peptide 1 (GLP-1) through activation...

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Main Authors: Qian Wang (Author), Mona Farhadipour (Author), Theo Thijs (Author), Emily Ruilova Sosoranga (Author), Bart Van der Schueren (Author), Laurens J. Ceulemans (Author), Ellen Deleus (Author), Matthias Lannoo (Author), Jan Tack (Author), Inge Depoortere (Author)
Format: Book
Published: Elsevier, 2024-10-01T00:00:00Z.
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