Bitter-tasting drugs tune GDF15 and GLP-1 expression via bitter taste or motilin receptors in the intestine of patients with obesity

• Үндсэн зохиолчид: Qian Wang (Зохиогч), Mona Farhadipour (Зохиогч), Theo Thijs (Зохиогч), Emily Ruilova Sosoranga (Зохиогч), Bart Van der Schueren (Зохиогч), Laurens J. Ceulemans (Зохиогч), Ellen Deleus (Зохиогч), Matthias Lannoo (Зохиогч), Jan Tack (Зохиогч), Inge Depoortere (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2024-10-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Objective: Growth differentiation factor 15 (GDF15), a stress related cytokine, was recently identified as a novel satiety signal acting via the GFRAL receptor located in the hindbrain. Bitter compounds are known to induce satiety via the release of glucagon-like peptide 1 (GLP-1) through activation...