Effects of Lactate Transport Inhibition by AZD3965 in Muscle-Invasive Urothelial Bladder Cancer

• Main Authors: Ana Silva (Author), Ana Félix (Author), Mónica Cerqueira (Author), Céline S. Gonçalves (Author), Belém Sampaio-Marques (Author), Adhemar Longatto-Filho (Author), Fátima Baltazar (Author), Julieta Afonso (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Warburg Effect is characterized by high rates of glucose uptake and lactate production. Monocarboxylate transporters (MCTs) are crucial to avoid cellular acidosis by internal lactate accumulation, being largely overexpressed by cancer cells and associated with cancer aggressiveness. The MCT1-spe...