The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase

• Main Authors: Kenneth R. Olson (Author), Tsuyoshi Takata (Author), Kasey J. Clear (Author), Yan Gao (Author), Zhilin Ma (Author), Ella Pfaff (Author), Karthik Mouli (Author), Thomas A. Kent (Author), Prentiss Jones (Author), Jon Fukuto (Author), Gang Wu (Author), Karl D. Straub (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

LCS-1, a putative selective inhibitor of SOD1, is a substituted pyridazinone with rudimentary similarity to quinones and naphthoquinones. As quinones catalytically oxidize H₂S to biologically active reactive sulfur species (RSS), we hypothesized LCS-1 might have similar attrib...